|Main Character: Las Vegas|
|Birth Date||October 1972|
|Portrayed By||Liz Vassey|
|First Appearance||Secrets and Flies|
Wendy is kind, caring person, who always does her job with care and detail. She often makes quick witted comments especially about Hodges. She also remains to be the only person to ever make Hodges speechless as Hodges had romantic feelings for Wendy however Wendy never officially returned them.
Wendy was born in 1972. 
She was once paid $600 for a cameo role in a horror movie after she left college. (The Chick Chop Flick Shop)
Simms worked in San Francisco, California for a time before moving to Las Vegas to take the DNA tech position (Secrets and Flies). It is revealed that she gets a job in the field in Portland, Oregon, and now lives there.
- In season 9, Liz Vassey was credited as a "special guest star"
- She has an interest in French neoclassical architecture and is allergic to aubergine. (Field Mice)
- Her blood type is B Negative. (Field Mice)
- In the season 11 episode Pool Shark, Wendy resigned from the Las Vegas crime lab to be part of a CSI team in Portland, where her sister lives.
- She has an uncle who also works in a DNA lab. (19 Down)
- She is a blood donor who donates together with Henry. (Field Mice)
- Season 6: Secrets & Flies, A Bullet Runs Through It, Part 2, Still Life, Werewolves, Daddy's Little Girl, Pirates of the Third Reich, Up in Smoke, I Like to Watch, Spellbound, Rashomama, Bang-Bang, Way to Go
- Season 7: Built to Kill: Part 2, Happenstance, Meet Market, Law of Gravity, Fallen Idols, Big Shots, Lab Rats, The Good, the Bad and the Dominatrix, Living Doll
- Season 8: Go to Hell, The Case of the Cross-Dressing Carp, The Chick Chop Flick Shop, Who and What, You Kill Me, Lying Down with Dogs, Bull, A Thousand Days on Earth, Drops' Out, The Theory of Everything, Two and a Half Deaths, For Gedda
- Season 9: For Warrick, The Happy Place, Let It Bleed, Leave Out All the Rest, Say Uncle, Woulda, Coulda, Shoulda, Young Man with a Horn, 19 Down, One to Go, The Grave Shift, Disarmed and Dangerous, Deep Fried and Minty Fresh, Miscarriage of Justice, Kill Me if You Can, Turn, Turn, Turn, No Way Out, Mascara, The Descent of Man, A Space Oddity, If I Had a Hammer..., The Gone Dead Train, Hog Heaven, All In
- Season 10: Family Affair, Ghost Town, Working Stiffs, Coup de Grace, Bloodsport, Death and the Maiden, The Lost Girls