| Main Character: Miami | |
 | |
| Name | Marisol (Delko) Caine |
| Gender | Female |
| Family | Eric Delko (brother) |
| City | Miami |
| Status | Deceased |
| Portrayed By | Alana De La Garza |
Marisol Delko Caine was Eric Delko's younger sister and the wife of Horatio Caine.
Season Four
Marisol came down with cancer. Because of the painful treatments, Eric occasionally bought marijuana to alleviate her pain and nausea. Afterward, Eric helped to feed her when she had no appetite. Eric's friends found out when the drug dealer ruined a crime scene by dropping though a skylight and then trying to save himself by mentioning that Eric buys drugs from him.
Marisol and Horatio were married between the episodes Shock and Rampage. She was shot by a Mala Noche sniper during the Rampage episode and later died from her injury. It was later discovered that the hit was ordered by a Mala Noche boss named Antonio Riaz, who found out about Marisol's family connections through his relationship as her marijuana dealer.
Not long after, Horatio and Delko follow Riaz to Brazil, and Horatio kills Riaz.