|Minor Character: Miami|
|Name||Marisol (Delko) Caine|
|Family|| Eric Delko (brother)|
Horatio Caine (husband)
Kyle Harmon (stepson)
|Portrayed By||Alana De La Garza|
|First Appearance||Seasons 4, 10|
Delko had a phone conversation with her brother after a sniper killed at least four people in the center of Miami. (Kill Zone)
Marisol came down with cancer. Because of the painful treatments, Eric occasionally bought marijuana to alleviate her pain and nausea. Afterward, Eric helped to feed her when she had no appetite. Eric's friends found out when the drug dealer ruined a crime scene by dropping through a skylight and then trying to save himself by mentioning that Eric buys drugs from him.
Marisol and Horatio were married between the episodes Shock and Rampage. She was shot by a Mala Noche sniper during the Rampage episode and later died from her injury. It was later discovered that the hit was ordered by a Mala Noche boss named Antonio Riaz, who found out about Marisol's family connections through his relationship as her marijuana dealer.
Not long after, Horatio and Delko follow Riaz to Brazil, and Horatio kills Riaz.
After being shot by Randy North, Horatio starts to have hallucinations because of the pain, then Marisol appeared to him and they started to talk. Horatio tells her that he misses her and that he wanted to go with her, but Marisol says to him that he must continue living because he has a life mission to complete and that he has people that needs him; she also tells him that she loves him. Marisol convinces Horatio to stand up and rescue Natalia who was about to die drowned in a car. He stands up, in spite of his wounds, and dives to rescue Natalia. Later through the episode, Horatio keeps remembering his wife and the happy moments he lived with her.