Madison Keaton is the illegitimate daughter of Raymond Caine and Susie Barnam Keaton (episode 208, "Big Brother"). In a later episode, Madison becomes terminally ill. Neither Horatio nor Susie are matches for a bone marrow transplant. Horatio convinces Yelina Salas (who had assumed Madison was Horatio's daughter before Horatio told her the truth) to have her son tested. Presumably, Ray Jr. is tested and proves to be a match, and Madison is cured.

She is played by Kyndell Rose Crowell.