Born to Kill is the Season 5 finale of CSI: Miami.
Horatio hunts for a serial killer who brands his victims with a "Y" mark. When an arrest is made, the alleged culprit is found to possess a supposed "killer gene" due to an extra Y chromosome. But just as the CSIs believe they've closed the case, the killings begin again.
- Ryan begins to go through several of his own files in preparation to rejoin the team.
- Calleigh and Jake share their first kiss.
- The song playing over the last few seconds of the finale is "Something to Believe In" by Aqualung, a British musician whose real name is Matthew "Matt" Hales.