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Minor Character: Las Vegas
Alisa Santiago
Name Alisa Santiago
Gender Female
Birth Date 1996
Family Julian Santiago (brother)
Marta Santiago (mother)
Unnamed father (deceased)
Diana Santiago (sister, deceased)
CityLas Vegas
Occupation Student
Pathology Serial Killer
Modus Operandi Arsenic poisoning
No. of Victims 4 killed
Status Institutionalized
Portrayed By Georgie Flores
First Appearance House of Hoarders

"Are you sure about that... You said it yourself, I'm sick."

Alisa Santiago was a serial killer and poisoner who appeared in season eleven of CSI: Crime Scene Investigation.


Alisa Santiago lived at home with her parents and siblings.

Her mother, Marta Santiago began developing a compulsion to hoard many items and objects from her life, leading to an additional development of "clutter-blindness," being unable to register items of clutter.

This eventually drove her father to his suicide after he had enough of his wife's compulsion.

Her brother, Julian Santiago couldn't wait to leave the crammed house and left immediately once he was old enough to work in a halfway house for orphaned teenagers which left Alisa and Diana by themselves with their mother which would eventually drive Alisa to madness and Diana to death.

Still in contact with her brother, she spoke to him regularly and Julian allowed her to work in his halfway house. This is where her taste for killing began.

Season Eleven

House of Hoarders

During one of Alisa's murders, her mother caught her burying the body. In an obscure attempt to protect her daughter from her herself and from murdering again, she chained her to a cot in a spare room, gagged her and blocked the door and floorspace under heaps of junk.

The LVPD went to Marta Santiago's house to inspect the overflowing house of rubbish where upon they found one of Alisa's victims after Nick Stokes accidentally stepped on the corpse.

The CSI team came and found four more of Alisa's victims and then found Alisa herself, tied up. The CSI's either believed Julian or Marta was the murderer, however, they were both wrong; it was Alisa.

Soon, enough evidence pointed out that Alisa was in fact the serial killer. Raymond Langston questioned her to which she responded how she enjoyed her killings.

After this, Marta and Julian were released. Alisa was institutionalized for her murders.

Modus Operandi

Alisa Santiago would lure male teenage orphans around her age and promise them sex with her. She would invite them to come to her house, to which they always replied a definite "yes." Once there, she would make them a meal or drink laced with arsenic which would kill them. She would then bury the bodies in her garden.

Known Victims

  • June 7, 2008: An unidentified boy
  • 2009:
    • May 11: Ryan Hoff
    • December 21: Derek Kennedy
  • April 10, 2010: Matthew Price


  • Alisa is the youngest serial killer of all in the CSI franchises so far.